Longevity Supplements: Evidence-Based Reviews

We review the clinical evidence behind the most discussed supplements and interventions for longevity and healthspan. Each guide summarizes what peer-reviewed research actually shows — not marketing hype.

Our approach: Every supplement guide is grounded in published clinical studies and systematic reviews. We rate evidence quality based on study design, sample sizes, and reproducibility across multiple trials.

Geroprotectors & Pharmacological Agents

NMN & NAD+

Nicotinamide mononucleotide for cellular energy and aging

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Rapamycin

mTOR inhibition and lifespan extension research

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Metformin

Geroprotective effects and the TAME trial

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Senolytics

Dasatinib, quercetin, fisetin — clearing zombie cells

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NAD+ & Sirtuin Pathway

Nicotinamide Riboside

NAD+ precursor for brain health and neuroprotection

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Resveratrol

Polyphenol activating SIRT1 for cellular defense

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Spermidine

Autophagy inducer for cardiovascular and brain health

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Mitochondrial & Metabolic Support

Molecular Hydrogen

Selective antioxidant with 10 verified clinical studies

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Urolithin A

Mitophagy activator for mitochondrial renewal

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CoQ10 / Ubiquinol

Mitochondrial electron transport and cardiac health

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Berberine

AMPK activator for glucose and lipid metabolism

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Essential Nutrients & Lifestyle

Vitamin D

Immune regulation, bone health, and aging markers

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Omega-3 Fatty Acids

Cardiovascular protection and brain health in aging

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Creatine

Cognitive and muscle performance in aging adults

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Caloric Restriction

Slowing epigenetic aging through dietary intervention

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Rapamycin

The mTOR inhibitor extending lifespan in every species tested

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Nicotinamide Riboside (NR)

The clinically validated NAD+ precursor

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Senolytics

Clearing zombie cells to reverse biological aging

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Disclaimer: These reviews summarize published research and are not medical advice. Always consult a qualified healthcare provider before starting any supplement regimen. Evidence ratings reflect the current state of peer-reviewed literature and may change as new studies are published.